Recombinant Mouse C-C motif chemokine 27 protein(Ccl27) (Active)

Volume: 100 µg. Other sizes are also available. Please contact us. Research Areas: Immunology Uniprot NO.: Q9Z1X0 Uniprot Entry Name: CCL27_MOUSE Gene Names: Ccl27,Ilc,Scya27 Species: Mus musculus (Mouse) Source: E.Coli Expression Region: 26-120aa Sequence: LPLPSSTSCC TQLYRQPLPS RLLRRIVHME LQEADGDCHL QAVVLHLARR SVCVHPQNRS LARWLERQGK RLQGTVPSLN LVLQKKMYSN PQQQN Protein Description: Partial of NM_011336 Tag Info: Tag-Free Mol. Weight: 10.9 kDa Biological_Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood lymphocytes is in a concentration range of 10-100 ng/ml. Purity: >98% as determined by SDS-PAGE and HPLC. Endotoxin: Less than 1.0 EU/µg as determined by LAL method. Form: Lyophilized powder Buffer: Lyophilized from a 0.2 µm filtered PBS, pH 7.4 Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias: CC chemokine ILC, CTACK, ESkine, IL-11 R-alpha-locus chemokine, ALP Relevance: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. May play a role in cell migration during embryogenesis. Nuclear forms may facilitate cellular migration by inducing cytoskeletal relaxation. Binds to CCR10. PubMed ID: 10329455; 10556532; 10588729; 16141072; 15489334; 10559234; 12133963 Function: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. May play a role in cell migration during embryogenesis. Nuclear forms may facilitate cellular migration by inducing cytoskeletal relaxation. Binds to CCR10. Involvement in disease: Subcellular Location: Isoform 1: Secreted, Nucleus Protein Families: Intercrine beta (chemokine CC) family Tissue Specificity: Isoform 1 is predominantly expressed in placenta and weakly in skin. Isoform 2 is predominantly expressed in testes and brain, weakly in kidney and liver and even lower in heart and muscle. Low expression of both isoforms in other tissues. Paythway: HGNC Database Link: UniGene Database Link: https: //www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=335946 KEGG Database Link: https: //www.genome.jp/dbget-bin/www_bget?mmu: 100039863 STRING Database Link: https: //string-db.org/network/10090.ENSMUSP00000137284 OMIM Database Link: